In 1952, twenty-three year old medical student Ernesto Guevara de la Serna (later better known as Ernesto Che Guevara) just one semester away from graduation, decides to postpone his last semester to accompany his twenty-nine year old biochemist friend Alberto Granado on his four month, 8,000 km long dream motorcycle trip throughout South America starting from their home in Buenos Aires. Their quest is to see things they've only read about in books...

When a band of outlaw bikers meet up with a group of peace loving hippies in a deserted ghost town, it seems the two groups find common ground in seeking liberation from society's rules. But trouble begins when one of the hippie girls is brutally murdered, and peaceful coexistence degenerates into hopelessness and violence.

Members of a motorcycle gang seek revenge for the death of one of their friends.

When a recent widower is consumed with regret, he embarks in a cross country motorcycle ride looking for absolution and to confront the mistakes of his past and unexpectedly discovers that life is about moving forward, one mile at a time.