In 1952, twenty-three year old medical student Ernesto Guevara de la Serna (later better known as Ernesto Che Guevara) just one semester away from graduation, decides to postpone his last semester to accompany his twenty-nine year old biochemist friend Alberto Granado on his four month, 8,000 km long dream motorcycle trip throughout South America starting from their home in Buenos Aires. Their quest is to see things they've only read about in books...