When four classmates from a small Massachusetts college move to New York to make their way, they're broke, adrift, and buoyed only by their friendship and ambition. There is kind, handsome Willem, an aspiring actor; JB, a quick-witted, sometimes cruel Brooklyn-born painter seeking entry to the art world; Malcolm, a frustrated architect at a prominent firm; and withdrawn, brilliant, enigmatic Jude, who serves as their center of gravity. Over the decades,...

Nate & Margaret centers on a 19 year old film student named Nate, and his best friend Margaret, a 52 year old spinster who dreams of being a stand up comedian. Nate's audacious classmate Darla sets him up on a date with James, which causes Nate's new life to shake apart his friendship with Margaret, who must now go find a life of her own.